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Oct 2026

ST3GAL1-mediated α-2,3 sialylation restrains CD105-TGFβRII signaling to attenuate EndMT-driven atherosclerosis.

BACKGROUND AND AIMS Endothelial-to-mesenchymal transition (EndMT) contributes to atherosclerotic plaque progression. Although endothelial sialylation is essential for vascular homeostasis, its role in EndMT remains poorly understood. This study investigated the role and underlying mechanism of α-2,3 sialylation in EndM...

Tian-Lan Xi, Qian Liu, Yu-Mei Dai et al. · 0 citations
Open access Oct 2026

Gut microbiota alterations associated with dietary inflammation and sarcopenia in humans and aged mice: insights from integrated metabolomic analysis.

Objective: To investigate the association between the dietary inflammatory index (DII) and sarcopenia risk in older adults and identify cross-species microbial signatures linking dietary inflammatory burden with muscle phenotypes. Methods: A total of 1048 older adults were enrolled, and multivariable logistic regressio...

Shan Li, Ke-Ke Ren, Xi-Lin Yang et al. · 0 citations

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