SHP2 induced 125I radiotherapy-resistant in cervical cancer via modulating ERK/E2F1/SKP2 and P53/AMPK/FOXO signaling induced apoptosis and proliferation
To elucidate the molecular mechanismthrough which SHP2 confers resistance to 125I radiotherapy in cervical cancer by promoting the ERK/E2F1/SKP2 pathway while antagonizing the P53/AMPK/FOXO pathway. Bioinformatics analysis was employed to identify SHP2 associated genes.In vivo experiments assessed tumor progression v...