Author

Shan-Shan Cai

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Open access Sep 2026

System biology analysis reveals circadian rhythm disorder associated with development and progression in colorectal cancer

The ClockProCRC system is developed and validated, which detects and quantifies intrinsic circadian misalignment in CRC and elucidates how circadian misalignment drives CRC progression trajectories, shapes clinical phenotypes, regulates disease manifestations, and reshapes the tumor microenvironment.

Shi-Qian Zhang, Shan-Shan Cai, Nai-Jing Hou et al. · npj Precision Oncology · 0 citations

Open access Jan 2026

From Germline Variants to Tumor Outcome: GWAS‐Based Functional Genomics Prioritizes Colorectal Cancer Susceptibility Genes and Links SMAD9 to Prognosis

Integrating statistical genetics, regulatory prediction, and locus‐directed experiments prioritized SMAD9, MAP3K2, FADS1, and ACTR1B as CRC susceptibility genes, and placed experimental bounds on the proposed MAP3K2 and ACTR1B mechanisms.

Chengguang Hu, Guang Yang, Han Xiong et al. · Human Mutation · 0 citations