Shang-Jun Bai

Precision covalent chemistry: Advances in selectivity-driven covalent drug design over the past five years.

Covalent inhibitors bind tightly and persistently to protein targets via covalent links with nucleophilic amino acids, yet unintended covalent modification of irrelevant proteins creates major safety risks and restricts their clinical use. To tackle this issue, researchers have shifted from reactivity-centered design t...