Open access
Sep 2026
Tumor-cell HMGB1 restrains CD8+ T-cell immunity during conventional fractionated radiotherapy.
Conventional fractionated radiotherapy (CFRT) remains a mainstay for many solid tumors, yet it often fails to elicit durable anti-tumor immunity. How CFRT engages tumor-cell programs to shape the immune microenvironment and determine therapeutic outcome remains unclear. Here we show in preclinical mouse models that CFR...
Chen Chen, Jia-Hong Shi, P. Cao et al.
· Cancer Letters · 0 citations