Author

Shannon C. Wall

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Open access Aug 2026

Bidirectional disruption of Lrrk2 function drives T cell dysregulation and an exhaustion-like immune response

It is suggested that bidirectional disruptions to normal LRRK2 function break immune homeostasis and immune cell function should be carefully considered when targeting LRRK2 kinase activity in patients with PD.

Robert C. Sharp, Shannon C. Wall, Jordan C. Follet et al. · bioRxiv · 0 citations