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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Shao-Feng Sun

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Open access Sep 2026

Identification of benzoxazine scaffold derivatives as novel CDK4 inhibitors for the treatment of cancer

Abstract Cyclin-dependent kinase 4, a pivotal regulator of cell cycle progression, is widely recognised as a therapeutic target for controlling tumour proliferation. Inspired by the reported CDK4 inhibitor PF-07220060, a series of novel benzoxazine derivatives were designed, synthesised, and evaluated for their biologi...

Chao Lin, Shao-Feng Sun, Hua-Teng Zhang et al. · 0 citations

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