PAQR3 Promotes Diabetic Tubulointerstitial Fibrosis by suppressing STUB1-mediated NOX4 ubiquitination.
Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease, and tubulointerstitial fibrosis (TIF) represents its final pathological hallmark. Progestin and adipoQ receptor 3 (PAQR3) has been implicated in metabolism and inflammation, but its role in DKD remains largely unexplored. Here, we report that P...