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Shao-Jiang Song

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Sep 2026

Hypoxia-activated 2-nitroimidazole-brusatol carbonate prodrugs for enhanced gastric cancer therapy with reduced systemic toxicity.

Tumor hypoxia, a characteristic feature of solid tumors that induces chemoresistance, enables the rational design of tumor-selective prodrugs. Brusatol (BST), a natural quassinoid with broad-spectrum antitumor effects, faces obstacles to clinical translation due to high systemic toxicity and insufficient tumor selectiv...

Ji-Chong Li, Xue-Lan Ma, Zi-Jian Liu et al. · 0 citations

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