Open access
Oct 2026
Roxadustat (FG-4592) Attenuates Renal Ischemia–Reperfusion Injury but Upregulates the NKG2D Ligand MICA
Ischemia–reperfusion injury (IRI) causes acute kidney injury (AKI) and transplant dysfunction. NKG2D ligands (human MICA and murine RAE-1/H60) drive immune activation, while Roxadustat (FG-4592) is reportedly renoprotective. We hypothesized that Roxadustat modulates these ligands in renal IRI. MICA expression was asses...
Huan Yang, N. Xu, Yong Wu et al.
· Biomolecules · 0 citations