Author

Shao-Min Zou

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Open access Sep 2026

Biohybrid nanovesicle-mediated targeted delivery of HSP90 inhibitor for enhanced sorafenib therapy of hepatocellular carcinoma after radiofrequency ablation

Hepatocellular carcinoma (HCC) presents significant therapeutic challenges due to enhanced liver cancer stem cell (LCSC) stemness and sorafenib resistance after radiofrequency ablation (RFA). To address these limitations, biohybrid nanovesicles (hNVs) are prepared by fusing milk-derived exosomes with sorafenib-resistan...

Ang-Feng Jiang, Xian-Fei Zhou, Jin-Chao Zhao et al. · Materials Today Bio · 0 citations

Review Open access Aug 2026

Molecular innate immune programs of tumor-associated macrophages in immune checkpoint blockade resistance: a staged framework from suppressive circuitry to translational bottlenecks

This review discusses TAM-mediated resistance to ICB as a molecularly regulated innate immune process that is dynamic and adaptive, and proposes that future TAM-directed therapies should move beyond broad macrophage depletion or nonspecific suppression and be matched to dominant macrophage programs, informed by spatial...

Yu-Zhe Huang, Jun-Qi Zhang, Kaipeng Tu et al. · Frontiers in Immunology · 0 citations