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Sharada Gopal

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Open access Aug 2026

A somatic checkpoint through NHR-49/HNF4α governs reproductive investment and longevity in C. elegans

The nuclear hormone receptor NHR-49, a homolog of mammalian PPARα and HNF4α, is a key transcriptional regulator of nutrition sensing and fatty acid metabolism in Caenorhabditis elegans. Here, we examine the role of NHR-49 in reproduction, including oocyte activation and ovulation. Loss of NHR-49 causes inappropriate oo...

Sharada Gopal, A. Chaturbedi, Tej Ramachandrula et al. · 0 citations

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