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Sharnvir S. Chattha

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Review Open access Sep 2026

Coronary microvascular dysfunction in HFpEF: pathophysiologic mechanisms, diagnosis, treatments, and the amplifying potential of sepsis

Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome in which coronary microvascular dysfunction (CMD) emerges as a central, prevalent pathobiologic substrate across multiple phenotypic clusters. CMD in HFpEF arises from intertwined mechanisms including systemic inflammation, impaired NO-c...

Sharnvir S. Chattha, Kush Kapadia, Daniel Lynch et al. · 0 citations

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