Open access
Aug 2026
Cell autonomous regional differences in oligodendrocyte lineage development and responses to oncohistone H3.3 K27M
Diffuse midline glioma, H3K27-altered (DMG), is a lethal midline brain tumor. Most DMG, unlike glioma arising in other regions, harbor histone H3.3 K27M (K27M) mutations. The basis for this anatomical selectivity remains unclear. Stem-like DMG cell transcriptomes most resemble oligodendrocyte precursor cells (OPCs). Us...
Jared M. Andrews, K. Budd, C. Kwon et al.
· Nature Communications · 0 citations