Transitioning from reactive to pretreatment DPYD testing through a system-wide screening program at a comprehensive cancer center.
544 Background: Fluoropyrimidines (FP), including 5-fluorouracil and capecitabine, are among the most commonly used systemic anticancer therapies. Deficiency of the dihydropyrimidine dehydrogenase (DPD) enzyme, encoded by the DPYD gene, is associated with an increased risk of severe, potentially life-threaten...