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Cyanopyridine-based derivatives as potent anticancer agents: Integrating in silico analysis and in vitro biological targeting of the EGFR/AKT/MAPK Signaling Cascade.
The increasing global incidence of cancer and the recurrent development of resistance to standard treatments require a rapid development of innovative, multi-targeted chemotherapeutic medicines. This study focused on the strategic design and synthesis of a range of new cyanopyridine derivatives (1a,b-5a,b) targeting th...