Cucurbitacin B attenuates LPS-induced skeletal muscle atrophy by inhibiting JAK2/STAT3 and suppressing proteasome activity.
BACKGROUND Skeletal muscle atrophy results from an imbalance between protein synthesis and degradation, commonly driven by chronic inflammation. Cucurbitacin B (CuB), a natural tetracyclic triterpenoid with anti-inflammatory properties, has shown therapeutic promise in various inflammatory diseases, but its role in lip...