Open access
Sep 2026
Bruceine A attenuates renal tubulointerstitial fibrosis by inhibiting the Wnt7a/PI3K/AKT pathway
Introduction Tubulointerstitial fibrosis (TIF) is a major pathological feature of progressive chronic kidney disease (CKD), yet effective pharmacological therapies remain limited. Bruceine A (BA), a quassinoid isolated from Brucea javanica, has been reported to exert renoprotective effects in glomerular diseases. Howev...
Shuang-Yu Li, Ren-Qing Wang, Tong Wang et al.
· Frontiers in Pharmacology · 0 citations