Oct 2026
Multi-omics integration reveals the CTSK-cholesterol metabolic axis and the cholesterol-RORA/LDLR paracrine axis in SPP1+ macrophages as mediators of 6PPD-quinone-induced idiopathic pulmonary fibrosis.
OBJECTIVE This study aimed to screen and identify potential biomarkers linking 6PPD-quinone (6PPD-Q) exposure to idiopathic pulmonary fibrosis (IPF), generating a mechanistic hypothesis for future experimental investigation and therapeutic development. METHODS 6PPD-Q-related genes and IPF-associated genes were obtain...
Qi-Xuan Wang, Yi-Ting Wu, Peng-Rui Du et al.
· Environmental Pollution · 0 citations