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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Sheng-Guang Ding

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Review Open access Sep 2026

Metabolite-driven dysfunction of intratumoral tertiary lymphoid structures: single-cell and spatial omics perspectives on cancer immune escape

This work proposes that metabolite-driven remodeling of the tumor microenvironment is a major cause of intratumoral TLS failure and outlines biomarker-guided strategies to restore TLS competence, including inhibition of tumor-derived tryptophan metabolism to promote TLS maturation and enhance anti-PD-1 efficacy.

Yi-Feng Wang, Yan Li, Shu-Juan Wei et al. · 0 citations

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