Drug resistance remains a major hurdle in antiviral drug development. This review highlights the “substrate envelope hypothesis”, a structure-based drug design (SBDD) paradigm that constrains the spatial boundaries and binding footprint of inhibitors within the conserved active site volume defined by natural viral subs...
Herpes simplex virus type 1 (HSV-1) causes widespread human infection, for which curative therapies remain unavailable. First-line TK-dependent nucleoside analogues such as acyclovir fail to eradicate latent virus and show limited activity against drug-resistant variants, highlighting an urgent unmet medical need. This...
Qiao-Mei Zhou, Bao-Hu Li, Ye-Hong Dai et al.· European journal of medicina...· 0 citations
Severe fever with thrombocytopenia syndrome virus (SFTSV), an emerging tick-borne bunyavirus with a case fatality rate of up to 30%, poses a growing threat to global public health. No approved specific antivirals are currently available. This perspective critically evaluates recent advances in the development of smal...
Zhou Tan, Ji-Wei Zhang, Chun-Hong Yin et al.· Journal of Medicinal Chemist...· 0 citations
Three effective countermeasures have been established: structure-based optimization of Mpro inhibitors, rational design of ExoN-evading nucleoside analogues, and synergistic combination therapies to combat emerging resistant SARS-CoV-2 variants.
Xianghan Bai, Bing Ye, Sheng-Hua Gao et al.· Molecules· 0 citations
The continuous evolution of SARS-CoV-2 and the emergence of drug-resistant variants underscore the urgent need for broad-spectrum antiviral agents targeting conserved viral proteins. The main protease (Mpro) represents a promising target due to its essential role in coronavirus replication. In this study, we report the...
Bing Ye, M. Lee, Letian Song et al.· European journal of medicina...· 0 citations
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