The Regulation of CCN1 Contributes to Skeletal Muscle Wasting in Chronic Kidney Disease.
BACKGROUND Sarcopenia is a prevalent complication of chronic kidney disease (CKD), yet reliable biomarkers remain limited. CCN1, a matricellular protein involved in cellular senescence, has been implicated in muscle wasting, but its role in CKD-associated muscle strength decline is incompletely understood. METHODS Se...