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Author

Sheng-Shou Hu

2 papers indexed here

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Aug 2026

PPIA-CD147 Interaction Mediates Immune-induced Cardiomyocyte Hypertrophy After Cardiac Xenotransplantation.

BACKGROUND Pathological myocardial hypertrophy constitutes a major impediment to the prolonged survival of heart xenotransplantation. Conventional approaches, including intensive antihypertensive therapy and growth factor receptor knockout, have demonstrated limited efficacy in mitigating this maladaptive remodeling. I...

Yuan Chang, Yi-Xuan Sheng, Renjie Tang et al. · 0 citations
Open access Aug 2026

FASN-mediated de novo lipogenesis promotes ceramide accumulation and myocardial damage in arrhythmogenic cardiomyopathy

It is shown that fatty acid synthase (FASN), the rate-limiting enzyme of de novo lipogenesis, is upregulated in cardiomyocytes of ACM patients and of a cardiomyocyte-specific Dsg2-mutant mouse model, identifying FASN as a candidate therapeutic target in ACM.

Zi-Rui Liu, Hao Cui, Tian-Shuo Yang et al. · 0 citations

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