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Open access Sep 2026

An ancestral mitochondrial DNA insertion disrupts RNAi and enables persistence of a novel mycovirus in Cryptococcus neoformans

RNA interference (RNAi) is a widely conserved genome-defense mechanism that protects eukaryotes against viruses and transposable elements. We previously showed that RNAi loss can lead to hypermutation and antifungal drug resistance in the human fungal pathogen Cryptococcus neoformans, illuminating the potential clinica...

Jun Huang, Connor J. Larmore, Timothy C. Davenport et al. · 0 citations
Open access Aug 2026

Mycodnaviridae is a clade of giant viruses that persistently infect zoosporic fungi

Giant viruses of the phylum Nucleocytoviricota have emerged as particularly notable due to their increasingly recognized impacts on eukaryotic genome evolution. Their origins are hypothesized to predate or coincide with the diversification of eukaryotes, and they have been detected in hosts that span the eukaryotic tre...

J. Myers, Frederik Schulz, Saleh Rahimlou et al. · 1 citation

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