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Author

Sheng Wang

2 papers indexed here

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Open access Sep 2026

Structure-based design of subtype-selective psychedelic analogs

Classical psychedelics exert hallucinogenic and therapeutic effects primarily through activation of serotonin 2 A receptor (5-HT2AR), offering promise as transformative treatments for neuropsychiatric disorders. However, their concurrent activation of 5-HT2BR—associated with cardiac valvulopathy—raises serious safety c...

Hui-Qiong Li, Lingjie Tang, Jin-Feng Zhang et al. · 0 citations
Open access Jul 2026

Molecular principles for graded activation of dopamine D1 receptor

G protein-coupled receptors (GPCRs) signal across a continuum of activation states, yet how ligands encode distinct signaling efficacies remains poorly understood. Here, we define the molecular mechanism underlying graded activation of the dopamine D1 receptor (D1R), a major therapeutic target for neuropsychiatric diso...

Xinyue Zhang, Yu Zheng, Heng Liu et al. · 0 citations

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