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Author

Shengxi Wu

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Open access Oct 2026

MSL2 orchestrates oligodendrocyte precursor cell cycle via H3K4me3 to prevent white matter defects in neurodevelopmental disorders.

Pathogenic variants in MSL2, a core component of the histone-modifying MSL complex, are associated with neurodevelopmental disorders (NDDs) and white matter abnormalities; however, their mechanisms of pathogenicity remain unknown. In this study, we identified three patients with NDD carrying MSL2 variants, all of whom...

Jie Yuan, Yu-Hao Dong, Kai-Xiang Zhang et al. · 0 citations
Open access Sep 2026

Anterior Cingulate Cortex Astrocytes Regulate Chronic Itch and Comorbid Negative Emotional Disorders in Mice

ABSTRACT Aims The anterior cingulate cortex (ACC) is widely recognized as a key brain region in modulating itch and itch‐associated behaviors. Though neuronal mechanisms are increasingly clarified, the role of ACC astrocytes remains poorly understood. Methods By employing a diphenylcyclopropenone (DCP)‐induced chronic...

Ze Fan, Xiao-Tong Shi, You Wu et al. · 0 citations
Open access Jul 2026

β-hydroxybutyrate restores social deficits by suppressing HDAC9 in the ACC of Shank3B-deficient mice.

It is found that KD ameliorates social deficits and induces systemic ketosis with marked elevation of β-hydroxybutyrate (BHB) in KO mice, and HDAC9 is identified as a potential therapeutic target for ASD-related social deficits.

Erling Hu, Jialong Li, Chuchu Qi et al. · 0 citations

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