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Open access Sep 2026

Diagnostic value of metagenomic next-generation sequencing for bacterial and fungal detection and its role in antimicrobial therapy adjustment in critically ill patients with non-resolving pneumonia

Abstract Introduction Early targeted antibiotic therapy is critical for improving outcomes in ICU patients with pneumonia unresponsive to initial treatment. Metagenomic next-generation sequencing (mNGS) is a unique diagnostic tool; however, its effectiveness for high-risk populations remains unclear. Methods This retro...

Jin-Wen Min, Zhi-Li Niu, Jing Yin et al. · 0 citations
Meta-analysis Open access Oct 2026

Renoprotective effects and safety of sodium–glucose cotransporter 2 inhibitors in diabetic chronic kidney disease

Background: Chronic kidney disease (CKD) is a major global health burden characterized by progressive loss of renal function and high cardiovascular morbidity and mortality. Sodium-glucose cotransporter 2 (SGLT2) inhibitors, initially developed as glucose-lowering agents, have demonstrated pleiotropic metabolic and car...

Xiu-Zhen Shi, Kai Fu, Min Hu et al. · 0 citations

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