TCF4-driven cathepsin S promotes papillary thyroid carcinoma via PI3K/AKT/mTOR.
Papillary thyroid carcinoma (PTC) usually has a good prognosis, but a subset of patients develops lymph node metastasis, radioiodine resistance and recurrence, and lacks effective molecular biomarkers and therapeutic targets. Cathepsin S (CTSS), a lysosomal cysteine protease, has been implicated in several malignancies...