Colitis, a chronic inflammatory bowel disease (IBD), is pathologically linked to immune dysregulation; however, the contribution of cellular metabolic alterations to its pathogenesis remains incompletely understood. In this study, untargeted metabolomic analysis revealed marked disruption of NAD+ metabolism, accompanie...
Yan-Ni Wu, Xiao-Han Yang, Xian-Yang Jin et al.· Journal of Physiology· 0 citations
As delayed childbearing becomes increasingly common, elucidating the mechanisms of age-related placental senescence is critical for the development of effective therapeutic strategies. Here, we integrate metabolomics, single-cell RNA sequencing, and spatial transcriptomics to uncover conserved features of aged placenta...
In vivo studies indicated that exogenous supplementation of TLCA significantly ameliorated hepatic glycolipid metabolism and improved overall liver function in LBW neonatal piglets, providing potential nutritional strategies to improve liver health in LBW piglets and a theoretical basis for using BAs as feed additives...
Tianle Gao, Hairong Liang, Meizheng Li et al.· Journal of Animal Science an...· 0 citations
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