Open access
Sep 2026
Charge-switching ionizable lipids lower the toxicity of lipid nanoparticles.
Lipid nanoparticles (LNPs) have great potential as nucleic acid delivery vehicles; however, they trigger the production of inflammatory cytokines, which limits their medical applications. Developing non-inflammatory LNPs is challenging because the LNP's ionizable lipid and the process of endosomal disruption are the ma...
Deng-Pan Liang, Ya-Lin Qi, He-Song Han et al.
· Nature Nanotechnology · 0 citations