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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Shengbin Zhou

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Jul 2026

Structure-Based Drug Design of Novel Indazole/Indolinone-Based Biaryl Derivatives as Oral IRAK4 Inhibitors for the Treatment of Inflammatory Diseases.

Pathological inflammation in multiple diseases arises from dysregulated innate immune signaling, wherein the interleukin-1 receptor-associated kinase 4 (IRAK4) acts as a critical node that mediates pro-inflammatory cascades and cytokine release downstream of toll-like and interleukin-1 receptors (TLR/IL-1R). Consequent...

Zhenwei Zhang, Xue Wang, Xuan Luo et al. · 0 citations
Aug 2026

Radical Mechanism and Stereochemical Control in Consecutive C-C Bond Formation by the Nonheme Iron Enzyme Hvm1.

Iron(II)/2-oxoglutarate-dependent (Fe/2OG) enzymes catalyze consecutive C-C bond formations to assemble complex heterobicyclic ring systems and generate three new stereocenters in piperazine alkaloids helvamide B and the arizonamides through C(sp3)-H activation─a transformation that remains challenging in synthetic che...

Shengbin Zhou, Jia-Peng Zhang, Jia-Yu Zuo et al. · 0 citations

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