AdvLIF: An Adversarially and Physics-Inspired Framework for Virtual Staining and Nucleus Segmentation.
AdvLIF is introduced, an adversarially regularized and physics-inspired framework for jointly generating H&E-like and complementary auxiliary modalities from IHC images and segmenting nuclei and achieves superior quantitative fidelity, exemplified by the lowest error on the IHC Quantification Difference metric.