Open access
Sep 2026
α-aminobutyric acid promotes tumor progression by polarizing macrophages through the ASNS-mTORC2 axis.
These findings uncover α-aminobutyric acid as a previously unrecognized signaling metabolite to control TAM polarization, providing insights into the metabolic crosstalk within the TME and offering a potential therapeutic target to improve cancer immunotherapy outcomes.
Fei Li, Xiao-Rong Xie, Tong-Ran Xu et al.
· Proceedings of the National... · 0 citations