Review
Open access
Oct 2026
Tumor microenvironment-driven therapeutic resistance in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most treatment-refractory malignancies, with limited and often transient benefit from chemotherapy, targeted therapy, immunotherapy, and radiotherapy. Therapeutic resistance is increasingly recognized as an ecosystem-level process arising from reciprocal intera...
Hong-Jia Li, Jia-Ning Cui, Xin Yang et al.
· Cancer Drug Resistance · 0 citations