Author

Shi-Qi Jia

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Open access Sep 2026

Novel 2,4-Pyrimidinediamine Derivative as Potent EGFR Inhibitor for NSCLC Treatment

Aberrant activation of EGFR drives the progression of non-small-cell lung cancer (NSCLC). As one of the most prevalent driver genes in NSCLC, EGFR represents a critical therapeutic target for patients with NSCLC. In this study, we synthesized 2,4-pyrimidinediamine derivative ZX-3. Compared to its lead compound ceritini...

Shi-Qi Jia, Xiao-Lin Lv, Jia Lv et al. · Molecules · 0 citations