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Open access Sep 2026

Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination‐Mediated c‐Myc Degradation

ABSTRACT Clear cell renal cell carcinoma (ccRCC) represents one of the most prevalent malignancies worldwide, characterized by high incidence and mortality rates. It is characterized by mitochondrial dysfunction with enhanced Warburg effect. In this study, we identify the sortilin‐related receptor 1 (SORL1) as a regula...

Ke-Yi Wang, Wei Song, Q. Bai et al. · 0 citations
Sep 2026

Programmed pathway selection for hierarchical assembly of peptides containing low-complexity aromatic-rich kinked segments.

Low-complexity, aromatic-rich kinked segments (LARKS) form thermoreversible, amyloid-like structures that are implicated in the disorder-to-order transition of condensates and phase-programmable materials. Despite their structural versatility, the transiently ordered/disordered conformation and multivalent interactions...

Xiu-Li Xu, Si-Qi Quan, Si-Qian Lu et al. · 0 citations

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