Author

Shi-Zhe Diao

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Open access Sep 2026

Syndecan-4 drives immune escape in microsatellite-stable colorectal cancer by suppressing the formation of cytotoxic effector T cells via the PRKCA–TNFα–NF-κB axis

Results indicate that high SDC4 expression in tumors from patients with CRC is negatively correlated with CD8 + T-cell accumulation in the TME, and targeting SDC4/PRKCA may reverse immunosuppression and enhance the efficacy of immunotherapy in MSS-type CRC.

Shun-Yi Wang, Yuehong Chen, Sheng-Zhi Ye et al. · Cell Death & Disease · 0 citations

#natural language process... Jun 2026

Zone of Proximal Policy Optimization: Teacher in Prompts, Not Gradients

Zone of Proximal Policy Optimization (ZPPO), inspired by Vygotsky's zone of proximal development, is introduced, which outperforms off/on-policy distillation and GRPO, with the largest gains at the smallest scale.

Byung-Kwan Lee, Ximing Lu, Shi-Zhe Diao et al. · arXiv.org · 2 citations