S. Kawai-Noma

Position-Dependent Activation and Repression by As(III) in an Engineered BetI Transcriptional Repressor

Arsenite [As(III)]-responsive transcriptional regulation is widely employed by microorganisms for detoxification and homeostasis. Engineering As(III)-responsive behavior into transcription factors that are intrinsically metal-insensitive remains challenging. Here, we introduced a third cysteine residue at different pos...