Author

Shih-Chi Su

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Open access Sep 2026

Siglec-7 orchestrates mitochondrial dynamics and metabolic reprogramming to restrain human NK cell cytotoxic function

Natural killer (NK) cells are innate lymphocytes that directly eliminate tumor and virus-infected cells by integrating signals from activating and inhibitory receptors, and their effector functions are tightly coupled to cellular metabolism. Given that the inhibitory receptor PD-1 reprograms T cell metabolism to shape...

Shih-Chi Su, Nai-Ting Tsao, Tzu-Lin Wang et al. · Journal of Biological Chemis... · 0 citations

Review Open access Oct 2026

Targeting oral cancer with curcumin and its structural analogs: molecular mechanisms, pharmacokinetic optimization, and clinical translation.

Curcumin is a naturally occurring polyphenol extracted from turmeric (Curcuma longa) and is known for its diverse biological functions, such as antioxidant, anti-inflammatory, anti-migratory, and anticancer activities. However, its use in clinical cancer treatment remains constrained due to challenges like limited abso...

Shih-Chi Su, Chun-Wen Su, Chia-Yi Lee et al. · Archives of pharmacal resear... · 0 citations