Author

Shih-Ming Huang

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Open access Sep 2026

Systems-Level Transcriptomic and Cellular Architecture of the Human Striatum in Schizophrenia and Bipolar Psychosis

Psychosis involves striatal circuit dysfunction, but the regional molecular and cellular changes remain unclear. We re-analyzed 215 postmortem RNA-seq samples (72 donors: 36 controls, 28 schizophrenia, 8 bipolar disorder with psychosis) from the nucleus accumbens, caudate and putamen, asking whether diagnosis-associate...

Wei-Hung Chan, Shih-Ming Huang, Hui-Chen Su et al. · Biology · 0 citations

Open access Aug 2026

Chronic Hypoxia-Induced Reprogramming of Smooth Muscle Cells: Insights into Transcription Factors, Cellular Stresses, and Therapeutic Implications

Background/Objectives: Chronic hypoxia promotes a shift in smooth muscle cells from a quiescent, contractile state to a highly proliferative phenotype, contributing to persistent vascular remodeling. This study examines primary human esophageal smooth muscle cells (HEsSMCs) exposed to hypoxia mimics, desferoxamine (DFO...

Sheng-Huei Wang, Yuan-Ming Tsai, Shu-Ting Liu et al. · Biomedicines · 0 citations