Author

Shih-Yu Chen

2 papers indexed here

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Open access Oct 2026

Oxidative stress-induced microglial CD22 upregulation impairs phagocytosis and exacerbates Huntington’s disease

Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal polyglutamine expansion in mutant huntingtin (mHTT) and is characterized by movement dysfunction and neuronal loss. Siglecs, a family of sialic acid-binding proteins, are expressed on brain microglia and implicated in Alzheimer’s dise...

Yan-Hua Lee, Jian-Jing Siew, Chia-Wei Lee et al. · Molecular Neurodegeneration · 0 citations

Open access Aug 2026

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

ABSTRACT Despite advancements in immune checkpoint blockade (ICB) therapy, breast cancer shows limited response to anti‐PD1/PD‐L1 treatments, emphasizing the need for alternative ICB targets. Here, we reveal that endocrine therapeutics, specifically tamoxifen, create an immunosuppressive yet primed tumor microenvironme...

M. A. Aberin, Saurabh Singh, Soumya Chatterjee et al. · Advancement of science · 0 citations