Open access
Oct 2026
Oxidative stress-induced microglial CD22 upregulation impairs phagocytosis and exacerbates Huntington’s disease
Huntington’s disease (HD) is a neurodegenerative disorder caused by an abnormal polyglutamine expansion in mutant huntingtin (mHTT) and is characterized by movement dysfunction and neuronal loss. Siglecs, a family of sialic acid-binding proteins, are expressed on brain microglia and implicated in Alzheimer’s dise...
Yan-Hua Lee, Jian-Jing Siew, Chia-Wei Lee et al.
· Molecular Neurodegeneration · 0 citations