Shijun Zhan

Plaque variant analysis of Entebbe bat virus reveals an envelope residue governing virus release from vertebrate cells.

Mechanistic investigation revealed impaired viral release in rS, a defect that can be rescued by neutralizing the pH of the secretory pathway, and suggests that D379N may elevate the pH threshold required for the E trimer to dimer conformational rearrangement, resulting in premature prM cleavage within early secretory...