Shikha Kataria

Transcriptomic and phenotypic characterization of Alzheimer’s disease risk genes in neurons and astrocytes highlights shared and cell type specific cellular mechanisms

Genome-wide association studies have identified nearly 100 genetic loci that affect Alzheimer’s disease risk. However, there is still a major challenge in linking genetic associations to genes and understanding their downstream cellular mechanisms of action. To address this gap, we performed single-cell transcriptomics...