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Shitong Qiao

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Open access Aug 2026

The SARS-CoV-2 S2′-helix compared to stem helix confers higher genetic barrier to antibody resistance

It is demonstrated that the S2′-helix in SARS-CoV-2 possesses a higher genetic barrier to antibody resistance than the stem helix, and combination therapy with S2′-helix-targeting antibodies synergistically suppressed the emergence of escape mutants selected by stem helix-directed antibodies.

Xuanjian Wang, Shitong Qiao, Zhiheng Bao et al. · 0 citations

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