Evaluation of Demineralised Freeze-dried Bone Allograft and Autologous Dentin Graft with Advanced Platelet-rich Fibrin in Socket Preservation: A Research Protocol
Introduction: Alveolar ridge resorption is initiated rapidly within weeks following tooth extraction, therefore successful implant outcomes depend upon preservation of alveolar ridge. Techniques like atraumatic extraction and socket grafting helps in reduction of bone loss. Demineralised Freeze-dried Bone Allograft (DFDBA) is a commonly used due to its osteoinductive properties which are enhanced when combined with Advanced Platelet Rich Fibrin (A-PRF). A-PRF enhances healing and regeneration of both soft and hard-tissues. Autologous Dentin Graft (ADG), derived from extracted teeth, mimics natural bone and offers osteoinductive and osteoconductive benefits. Radiographic and histological analysis along with clinical evaluation are reliable methods to assess outcomes. Need of the study: The ADG eliminates the need for a second surgical site and reduces patient morbidity. Furthermore, the combined effect of ADG with A-PRF has not yet been evaluated, highlighting the need for this study. Aim: To assess and compare the effectiveness of DFDBA with A-PRF and ADG with A-PRF in socket preservation using clinical, radiographical, and histological analysis. Materials and Methods: This randomised controlled clinical trial compares DFDBA with A-PRF and ADG with A-PRF in socket preservation. The trial will be conducted at the Department of Periodontics, Sharad Pawar Dental College, Sawangi (Meghe), Wardha, from May 2025 to June 2026, which will involve 10 participants in each group. Participants will be randomly assigned to one of two groups: (a) Socket preservation performed using DFDBA with A-PRF; (b) Socket preservation performed using ADG with A-PRF. Cone Beam Computed Tomography (CBCT) will be performed postoperatively and at four months, along with clinical evaluation and implant placement. Bone biopsies obtained during implant placement will be analysed histomorphometrically in a blinded manner. Statistical analysis will be performed using paired and unpaired Student’s t-tests, with a p-value <0.05 will be considered statistically significant.