Aug 2026
GSK3β-FBXW7 axis regulates MAFB protein stability through ubiquitin-mediated proteasome degradation.
FBXW7, the substrate recognition component of the SCFFBXW7 E3 ubiquitin ligase complex, functions as a tumor suppressor by regulating cell cycle progression, stem cell maintenance, and cellular differentiation. Loss of FBXW7 contributes to hematopoietic malignancies and promotes monocyte-to-macrophage differentiation....
S. Chowdhury, Prasannajit Sahoo, A. Shome et al.
· Biochimica et biophysica act... · 0 citations