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Shiwei Sun

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Aug 2026

Rational design of halogen-substituted near-infrared fluorescent probes for butyrylcholinesterase: from drug screening to imaging and therapeutic evaluation in Alzheimer's disease.

Monitoring butyrylcholinesterase (BuChE) activity is crucial for tracking Alzheimer's disease (AD) progression and evaluating therapeutics; however, high-performance near-infrared (NIR) probes with rapid response and clear design principles remain scarce. Here, we report a series of dicyanoisophorone-based NIR fluoresc...

Lin Jiang, Jian-Qin Yan, Chaolong Liu et al. · 0 citations
Open access Aug 2026

Discovery of Virulence Attenuator of Chromobacterium violaceum CV026 From Marine‐Derived Fungus Aspergillus ochraceus LSD‐13 by Inhibiting Quorum Sensing and Destroying Biofilm

Targeted quorum‐sensing (QS) represents a promising approach to combat multidrug‐resistant infections. In this study, an undescribed pyrazine derivative 5‐isobutyryl‐1,4‐dihydropyrazine‐2,3‐dione (1) together with three known compounds (2‐‐4) were isolated from the marine‐derived fungus Aspergillus ochraceus LSD‐13. Co...

Xinyi Li, Hui Wang, Yibo Wu et al. · 0 citations

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