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Shobhit Gairola

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Open access Oct 2026

Gramine Suppresses Myofibroblast Activation and ECM Accumulation in Renal Fibrosis by Targeting the NF-κB/NLRP3 and TGF-β1/Smad Pathways.

Chronic kidney disease (CKD) is driven by persistent inflammation and progressive fibrosis, leading to irreversible renal damage. Gramine (GMN), an indole alkaloid, has broad pharmacological benefits. However, its therapeutic potential against renal fibrosis remains unexplored. This study investigates the antifibrotic...

Shobhit Gairola, A. Bhatta, Tushar Mishra et al. · 0 citations

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