Shorog M. Alotaiby

Mechanistic insights into antioxidant and antibacterial effects of indole-pyrazole-carbohydrazide hybrids through density functional theory, docking, and molecular dynamics studies

A new series of indole-pyrazole-carbohydrazide derivatives ( IH-1-IH-5 ) was synthesized through acid-catalyzed condensation of 1H-indole-5-carbaldehyde with substituted pyrazole-5-carbohydrazides, aiming to develop multifunctional antioxidants and antibacterials. In2,2′-diphenyl-1-picrylhydrazyl (DPPH) assays, ele...